6-Thioguanine - efficacy and safety in chronic active Crohn's disease
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چکیده
منابع مشابه
Safety and efficacy of nitric oxide in chronic lung disease.
BACKGROUND Therapies for neonatal chronic lung disease (CLD) of prematurity have had limited success. AIMS To determine whether inhaled nitric oxide (INO) administered to very low birthweight infants with developing CLD might improve oxygenation without adverse effects. METHODS Subjects were 10-30 days of age, birth weight < 1250 g, with developing or established CLD, and requiring mechanic...
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We here report a case of a young man who presented to his general practitioner with diarrhea. Inflammatory bowel disease was suspected and a colonoscopy showed aphthous lesions suggestive of Crohns' disease but biopsies revealed eggs of Enterobius vermicularis. When treated for this parasite, his symptoms were alleviated and a followup colonoscopy revealed a normal colon and distal ileum. Enter...
متن کاملEffect of 6-Thioguanine and Methyl-6-Thioguanine on stability of DNA duplexes
6-Thioguanine (isG) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia. Despite its long-standing clinical use, little is understood of the molecular basis of the cytotoxicity associated with 6SG. Research has shown that 6SG is incorporated into DNA during replication after whic...
متن کاملScheduling of arabinosylcytosine and 6-thioguanine therapy.
SUMMARY Mice treated simultaneously with 1-0-D-arabinofuranosyl-cytosine (ara-C) and 6-thioguanine (6-TG) were protected from the lethal effects of 6-TG. No protection was afforded if ara-C was given 16 hr before the 6-TG. DNA synthesis in mouse bone marrow was immediately depressed to 3 to 12% of that of control in various experiments, after treatment with ara-C, 10 to 20 mg/kg; it then reboun...
متن کاملPharmacology of 6-Thioguanine in Man1
6-Thioguanine (6-TG) was administered to 15 patients with acute leukemia and to 9 with solid tumors in 32 experiments, as part of Phase I testing of 6-TG. 6-TG and metabolites were measured by labeling the 6-TG with radiosulfur. The levels of 6-TG and metabolites were measured in blood and urine after p.o. and i.v. dosage. Incorporation into DNA and RNA of the bone marrow was measured. Blood le...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2003
ISSN: 0269-2813
DOI: 10.1046/j.1365-2036.2003.01440.x